Two Promising Drugs for Alzheimer’s & Aging with Jon Berner (Science Backed)

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Psychiatrist Jon Berner reveals startling new evidence that two old, cheap drugs may hold the keys to slowing aging and reversing diseases like Alzheimer’s and chronic fatigue. From hidden Harvard data to firsthand clinical stories, this conversation unpacks the science, the mystery, and the moral tension behind medicine’s quiet revolution. Each turn brings a new question: what if the future of longevity has been here all along?

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Timestamps:
0:00 Intro – The forgotten anti-aging drug
0:38 Lithium’s comeback and Harvard’s Alzheimer’s discovery
3:24 Why medicine ignored a $40 cure
6:12 The dose no one agrees on
10:30 When patients start feeling decades younger
18:40 Side effects, myths, and real-world risks
46:19 The pivot – from lithium to rapamycin
47:20 How rapamycin rewires chronic fatigue
1:03:00 The dose dilemma: one pill or too little to matter?
1:26:11 Could this reset the body’s aging clock?

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Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!