Brain Repair: The Ketamine Combo Treatment for Depression and Chronic Pain

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Brain Disorder Expert: Tackling Alzheimer's & Other Brain Disorders with LITHIUM: https://www.youtube.com/watch?v=ebj-3MuAKRs

Check out Woodinville Psychiatric: https://www.woodinvillepsychiatric.com/

Matt and psychiatrist Jon Berner discussed the potential of rapamycin and ketamine for treating severe depression and chronic pain, focusing on their impact on microglia and brain inflammation. They touch on how microglia, a type of immune cell found in the central nervous system that help protect the brain against infections, clear debris, and respond to injuries, shifts from an inflammatory to a reparative state in response to rapamycin and ketamine treatment. They also dive into clinical case studies of ketamine and rapamycin combinations and the complicated topic of how regulatory reform and AI collaboration might advance medical innovation.

Jon has been in solo psychiatric practice at Woodinville Psychiatric in Washington since 1997. He spent several years working at the Monroe Correctional Complex, a Washington State Department of Corrections prison. His specialties include brain disorders, particularly bipolar and psychotic illnesses, complex pain, addiction, and "undiagnosed" neuropsychiatric syndromes, and other general psychiatric disorders such as anxiety and depression. Jon has published multiple scientific papers about various topics in the realm of mood disorders and treatments for them. He holds an M.D and a PhD in neuroscience from the University of California, Los Angeles and a B.A. in psychology from Harvard University.

0:00 Introduction
0:56 An interest in ketamine and rapamycin + the stability-plasticity dilemma
11:23 CSF-1 inhibitors and angry microglia
17:02 Tying things together
25:57 Ketamine's addictive properties
29:43 The ketamine-rapamycin interaction
40:33 Why can't we get people off fentanyl + a potential way to tackle the problem
46:58 Two important notes Jon wants to share
1:01:49 Wrapping up

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

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Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!