This Fat-Derived Hormone Reverses Heart Aging (New Science)

For all references and a written breakdown, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/the-fat-derived-hormone-that-could?r=40ekz2

Exciting new research in 2025 suggests that a fat-derived hormone called 12,13-diHOME may help to reverse age-related decline in cardiac function and slowing heart aging. The best part? You can boost it naturally — not with drugs or supplements, but with a simple lifestyle intervention that’s accessible today.

In this video, we break down the latest metabolic health and longevity science on how this lipid hormone made by brown fat cells declines with age, how that hormonal drop contributes to cardiovascular aging, and what evidence-based lifestyle interventions can increase 12,13-diHOME to more youthful levels. If you care about heart health, reversing aging, and boosting metabolic resilience, this is essential science you should know.

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*Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2

PRIOR RELATED VIDEOS
Cold Exposure and Oxylipins: https://youtu.be/VMR0T37GMCw
How We Got Omega-6 Wrong: https://youtu.be/3vy6EnsWT0M
Tallow Fries Scam: https://youtu.be/3rwbL5HrRUc

Chapters:
0:00 – Intro: Fat-Derived Hormone That Anti-Ages the Heart
0:39 – New 2025 Research on Aging & Cardiovascular Health
1:24 – Brown Fat as a Hormone-Secreting Endocrine Organ
2:32 – 12,13-diHOME Levels Decline With Age
3:02 – Brown Fat Transplants Anti-Age the Heart
6:14 – Mechanisms of Cardiovascular Anti-Aging
7:58 – Summary: Fat Hormones, Metabolism & Heart Longevity
8:42 – Longevity Hack: The Best ‘Chapter’ for Heart Health
10:32 – Cold Exposure Boosts 12,13-diHOME & Heart Health
11:50 – Insulin Sensitivity, BMI & 12,13-diHOME Levels
12:52 – Tracking Fat Metabolism With Glowing Fat Cells
13:47 – Final Summary: Boosting Fat Hormones for Heart Anti-Aging

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