Endocrinology | Growth Hormone

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Ninja Nerds!
In this endocrine physiology lecture, Professor Zach Murphy presents a comprehensive overview of Growth Hormone (GH), detailing its regulation, mechanisms of action, and systemic effects across multiple tissues. This hormone plays a critical role in growth, metabolism, and cellular repair—and its balance is essential for normal development and adult homeostasis.

We begin by discussing how GH is secreted from the anterior pituitary in a pulsatile fashion, under the stimulatory influence of GHRH and the inhibitory control of somatostatin from the hypothalamus. The lecture explains how GH acts both directly on tissues and indirectly through the hepatic production of insulin-like growth factor 1 (IGF-1), which mediates many of its growth-promoting effects.

You’ll learn how GH and IGF-1 affect bone growth, muscle protein synthesis, lipolysis, and glucose metabolism, with a special focus on the JAK-STAT signaling pathway. We also explore the negative feedback loops that regulate GH and IGF-1 secretion.

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